Phytochemical profiling of Curcuma kwangsiensis rhizome extract, and identification of labdane diterpenoids as positive GABAA receptor modulators.

@article{Schramm2013PhytochemicalPO,
  title={Phytochemical profiling of Curcuma kwangsiensis rhizome extract, and identification of labdane diterpenoids as positive GABAA receptor modulators.},
  author={Anja Schramm and Samad N Ebrahimi and Melanie Raith and Janine Zaugg and Diana Rueda and Steffen Hering and Matthias Hamburger},
  journal={Phytochemistry},
  year={2013},
  volume={96},
  pages={318-29}
}
An ethyl acetate extract of Curcuma kwangsiensis S.G. Lee & C.F. Liang (Zingiberaceae) rhizomes (100 μg/ml) enhanced the GABA-induced chloride current (IGABA) through GABAA receptors of the α1β2γ2S subtype by 79.0±7.0%. Potentiation of IGABA was measured using the two-microelectrode voltage-clamp technique and Xenopus laevis oocytes. HPLC-based activity profiling of the crude extract led to the identification of 11 structurally related labdane diterpenoids, including four new compounds… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 42 references

Handbook of Chinese Medicinal Plants – Chemistry, Pharmacology

  • W. Tang, G. Eisenbrand
  • 2011
Highly Influential
3 Excerpts

Anticonvulsant activity of bisabolene

  • P.A.M, C. V. Esguerra
  • 2012

nervous system drugs

  • G.G, S. Eun, S. H. Shim
  • NeuroRx
  • 2012

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