Phytochemical modulation of the Akt/mTOR pathway and its potential use in cutaneous disease

@article{Leo2014PhytochemicalMO,
  title={Phytochemical modulation of the Akt/mTOR pathway and its potential use in cutaneous disease},
  author={Michael S. Leo and Raja K Sivamani},
  journal={Archives of Dermatological Research},
  year={2014},
  volume={306},
  pages={861-871}
}
The mechanistic target of rapamycin (mTOR) is involved in the regulation of cellular growth, proliferation, lipid synthesis, and protein translation. The mTOR pathway involves two complexes: the mechanistic target of rapamycin complex 1 (mTORC1) and the mechanistic target of rapamycin complex 2 (mTORC2). Both mTOR complexes have been implicated in the development and progression of various skin diseases including melanoma, psoriasis, and acne vulgaris. Here, we review the role of both mTORC1… CONTINUE READING
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