Phytochemical and pharmacological study of Sedum dendroideum leaf juice.

Abstract

The fresh juice from leaves of Sedum dendroideum Moc & Sessé (Crassulaceae) is used in Brazilian traditional medicine for the treatment of gastric and inflammatory disorders. The present investigation was carried out to evaluate in vivo antinociceptive and anti-inflammatory activities of this plant material. The oral administration (0.1-1g/kg) of the lyophilized Sedum dendroideum juice (L J) caused a significant dose-related reduction of acetic acid-induced writhing response (ID(50)=631 mg/kg) and inhibited croton oil-induced ear oedema formation (66% inhibition at 1g/kg) in mice. In the formalin-induced nociception in mice, L J (1g/kg) only inhibited the second phase of nociception (46%). Phytochemical investigation revealed four known kaempferol glycosides, here, described at the first time for this species. These flavonoids probably explain the antinociceptive and anti-inflammatory effects of the fresh juice of Sedum dendroideum.

Cite this paper

@article{Melo2005PhytochemicalAP, title={Phytochemical and pharmacological study of Sedum dendroideum leaf juice.}, author={Giany Oliveira de Melo and David do Carmo Malvar and Frederico Argollo Vanderlinde and Priscilla A Pires and Wellington da Silva C{\^o}rtes and Pedro Germano Filho and Michelle Fraz{\~a}o Muzitano and Carlos Roland Kaiser and S{\^o}nia Soares Costa}, journal={Journal of ethnopharmacology}, year={2005}, volume={102 2}, pages={217-20} }