Phytochemical Study and Evaluation of the Cytotoxic Properties of Methanolic Extract from Baccharis obtusifolia

@article{RomeroBenavides2018PhytochemicalSA,
  title={Phytochemical Study and Evaluation of the Cytotoxic Properties of Methanolic Extract from Baccharis obtusifolia},
  author={Juan Carlos Romero-Benavides and Gina C Ortega-Torres and Javier Villacis and Sara L. Vivanco-Jaramillo and Karla I Galarza-Urgil{\'e}s and Natalia Bail{\'o}n-Moscoso},
  journal={International Journal of Medicinal Chemistry},
  year={2018},
  volume={2018}
}
Some species of the Baccharis genus have been shown to possess important biomedical properties, including cytotoxic activity. In this study, we examined the cytotoxic effect of methanol extract from Baccharis obtusifolia (Asteraceae) in cancer cell lines of prostate (PC-3), colon (RKO), astrocytoma (D-384), and breast (MCF-7). The methanolic extract displayed the largest substantial cytotoxic effect in lines of colon cancer (RKO) and cerebral astrocytoma (D-384). Chromatographic purification of… 

Figures and Tables from this paper

Cytotoxicity of Lentinus isolates mycelial extracts on human colorectal carcinoma HCT-116 cells

The mycelia of 15 Lentinus isolates tested can be considered as potential sources of cytotoxic compounds for colon cancer, however, furtherance of the cytotoxicity and other bioactivity profiling of Lentinu mycelial extracts is highly recommended.

Synthesis and Evaluation of Biological Activities of Bis(spiropyrazolone)cyclopropanes: A Potential Application against Leishmaniasis

The results that are presented here represent a first screening, indicating two derivatives of bis(spiropyrazolone)cyclopropanes as good candidates for the treatment of leishmaniasis and have good specificity against parasites with respect to mammalian cells.

Sakuranetin and its therapeutic potentials – a comprehensive review

This review summarizes all the reported investigations with SKN for its health-beneficial roles and can be used as a guideline for future studies.

Synthesis, Characterization and Anti-Cancer Therapeutic Potential of Withanolide-A with 20nm sAuNPs Conjugates Against SKBR3 Breast Cancer Cell Line

These findings provide a foundation to further progress how they can overcome cancer drug resistance by conjugating active drugs in combination with AuNPs through optimizing the effective drug concentration and removing the surface barrier.

Pharmacology and Phytochemistry of Ecuadorian Medicinal Plants: An Update and Perspectives

The use of plants as therapeutic agents is part of the traditional medicine that is practiced by many indigenous communities in Ecuador. The aim of this study was to update a review published in 2016

References

SHOWING 1-10 OF 28 REFERENCES

Baccharis (Compositae): a review update

The Baccharis genus is an important source of natural medicinal products and its traditional and folkloric uses, phyto-constituents and pharmacological and toxicological reports of the prominent species of this genus are described.

Anti-inflammatory activity of four Bolivian Baccharis species (Compositae).

Chemical composition and biological activity of the essential oil of Baccharis obtusifolia Kunth from Loja, Ecuador

The chemical composition and biological activity of the essential oil of B. obtusifolia (Asteraceae) are reported for the first time and showed significant antibacterial and antifungal activity.

Biological activity of five antibacterial flavonoids from Combretum erythrophyllum (Combretaceae).

Trypanocidal flavonoids from Trixis vauthieri.

The crude extract of Trixis vauthieri (Asteraceae) was active against the trypomastigote forms of Trypanosoma cruzi, the protozoan that causes Chagas' disease. Bioassay-guided fractionation of this

Antioxidative activity of flavonoids from thyme (Thymus vulgaris L.)

During the course of our study on the isolation and structural elucidation of antioxidants from the spices of the family Labiatae, we found that the diterpenoids from rosemary1'2) and sage,3) and

Antioxidant activity and flavonoid content of Clusia fluminensis Planch. & Triana.

It can be inferred that the acetonic extract of C. fluminensis fruits is an interesting target for the search of substances with antioxidant activity, especially flavonoids, through the scavenging of the stable free radical DPPH and the determination of flavones and flavonols content.

Flavonoids and triterpenes from the nest of the stingless bee Trigona spinipes

The isolation of sakuranetin, kaempferol 7-methyl ether, and aromadendrin 7- methyl ether from both Trigonas spinipes'nest and the exudate from Eucalyptus, may suggest this species as a botanical origin of the nest constituents of these stingless bee in the Northeast of Brazil.