Phytochemical Characterization of the Leaves of Mitragyna Speciosa Grown in USA

@article{Len2009PhytochemicalCO,
  title={Phytochemical Characterization of the Leaves of Mitragyna Speciosa Grown in USA},
  author={Francisco Le{\'o}n and Eman Habib and Jessica E Adkins and Edward B. Furr and Christopher R. McCurdy and Stephen J. Cutler},
  journal={Natural Product Communications},
  year={2009},
  volume={4}
}
Mitragyna speciosa (Rubiaceae) has traditionally been used in the tropical regions of Asia, Africa and Indonesia as a substitute for opium. Indole alkaloids are the most common compounds that have been isolated. We investigated the constituents of the leaves of M. speciosa that was grown at the University of Mississippi. Several alkaloids were isolated, including ajmalicine, corynantheidine, isomitraphylline, mitraphylline, paynantheine, isocorynantheidine, 7-hydroxymitragynine and mitragynine… 

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References

SHOWING 1-10 OF 27 REFERENCES
Isolation and characterization of novel benzoates, cinnamates, flavonoids, and lignans from Riesling wine and screening for antioxidant activity.
TLDR
A German Riesling wine has been fractionated with the aid of countercurrent chromatography and the structures of 101 compounds were established by mass spectrometry and NMR spectroscopy, finding forty-four compounds exhibited a phenolic or benzylic structure.
Molecular analysis of the genus Mitragyna existing in Thailand based on rDNA ITS sequences and its application to identify a narcotic species: Mitragyna speciosa.
TLDR
This method provides an effective and accurate identification of M. speciosa using nucleotide sequences of internal transcribed spacers and the 5.8S coding region of nuclear ribosomal DNA of the Mitragyna species.
Saponins from Zygophyllum propinquum
Two new triterpenoid saponins zygophylosides D and E have been isolated from Zygophyllum propinquum. Their structures were elucidated as 3-O-[β-d-2-O-sulphonylquinovopyranosyl]-quinovic acid and
Camptothecins and two new monoterpene glucosides from Ophiorrhiza liukiuensis.
Two new monoterpene glucosides, demethylsecologanol and 3'''-O-glucosylsenburiside II, were isolated from Ophiorrhiza liukiuensis (Rubiaceae) together with 23 known compounds, including camptothecins
...
...