• Corpus ID: 12884667

Phytic acid down-regulates IL-8 secretion from colonic epithelial cells by influencing mitogen-activated protein kinase signaling pathway.

  title={Phytic acid down-regulates IL-8 secretion from colonic epithelial cells by influencing mitogen-activated protein kinase signaling pathway.},
  author={Joanna Wawszczyk and Arkadiusz Orchel and Małgorzata Kapral and Andrzej Hollek and Ludmiła Wȩglarz},
  journal={Acta poloniae pharmaceutica},
  volume={69 6},
Phytic acid (IP6) is an essential component of high fiber diet physiologically present in human large gut. It has been recognized to possess various significant health benefits effects including chemopreventive and have antineoplastic activity against various types of cancer. Moreover, its role in immune response through modulation of the secretion of proinflammatory cytokines and chemokines has been postulated. One of the signal transduction pathways involved in a variety of inflammatory… 
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Overview of Inositol and Inositol Phosphates on Chemoprevention of Colitis-Induced Carcinogenesis
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Soybean glycinin disrupted intestinal structural integrity related to aggravation of apoptosis and downregulated transcription of tight junction proteins in the intestine of juvenile grass carp (Ctenopharyngodon idella)
Glycinin aggravated apoptosis associated with both extrinsic and intrinsic signalling and disrupted TJ related to HNF-4α signalling in the midgut and hindgut, ultimately disrupting the intestinal structural integrity of grass carp.
Drug-likeness of Phytic Acid and Its Analogues
Out of 50 selected analogues of phytic acid, 42 structures interact well with the chosen drug targets, and the best interacting structures are 1-diphosinositol pentakisphosphate and 2,3,4,5,6-pentaphosphonooxycyclohexyl dihydrogen phosphate.
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