Phytantriol and glyceryl monooleate cubic liquid crystalline phases as sustained-release oral drug delivery systems for poorly water-soluble drugs II. In-vivo evaluation.

@article{Nguyen2010PhytantriolAG,
  title={Phytantriol and glyceryl monooleate cubic liquid crystalline phases as sustained-release oral drug delivery systems for poorly water-soluble drugs II. In-vivo evaluation.},
  author={Tri-Hung Nguyen and Tracey Hanley and Christopher J. H. Porter and Ian Larson and Ben J Boyd},
  journal={The Journal of pharmacy and pharmacology},
  year={2010},
  volume={62 7},
  pages={856-65}
}
OBJECTIVES Lipid-based liquid crystals formed from phytantriol (PHY) and glyceryl monooleate (GMO) retain their cubic-phase structure on dilution in physiologically relevant simulated gastrointestinal media, suggesting their potential application as sustained-release drug-delivery systems for poorly water-soluble drugs. In this study the potential of PHY and GMO to serve as sustained-release lipid vehicles for a model poorly-water-soluble drug, cinnarizine, was assessed and compared to that of… CONTINUE READING
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Effect of cholesterol and fatty acids on the molecular interactions of fengycin with stratum corneum mimicking lipid monolayers

  • M Eeman
  • Langmuir
  • 2009
Highly Influential
3 Excerpts

Interfacial and emulsifying properties of lipopeptides from Bacillus subtilis

  • M Deleu
  • Colloid Surface Physicochem Eng Aspect
  • 1999
Highly Influential
3 Excerpts

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