Phytanic acid a-oxidation: decarboxylation of 2- hydroxyphytanoyl-CoA to pristanic acid


The degradation of the first intermediate in the aoxidation of phytanic acid, 2-hydroxyphytanoyl-CoA, was investigated. Human liver homogenates were incubated with 2-hydroxyphytanoyl-CoA or 2-hydroxyphytanic acid, after which formation of 2-ketophytanic acid and pristanic acid were studied. 2-Hydroxyphytanic acid was converted into 2-ketophytanic acid and… (More)


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