Physostigmine inhibition of 3',5'-cyclic AMP phosphodiesterase from cat sciatic nerve.

Abstract

This study was designed to determine whether cholinergic drug interaction with cyclic (c) AMP phosphodiesterase (PDE) might account for part of the effects of this class of drugs at the neuromuscular junction. The activity levels of both high- and low-affinity forms of cAMP PDE from cat sciatic nerve were examined for drug inhibition or activation. Of the… (More)

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