Physostigmine increases the dose of propofol required to induce anaesthesia.

@article{Fassoulaki1997PhysostigmineIT,
  title={Physostigmine increases the dose of propofol required to induce anaesthesia.},
  author={Argyro G Fassoulaki and Constantine D Sarantopoulos and C Derveniotis},
  journal={Canadian journal of anaesthesia = Journal canadien d'anesthesie},
  year={1997},
  volume={44 11},
  pages={1148-51}
}
PURPOSE This prospective, randomized, double-blind study was performed to determine the effect of administration of physostigmine on the dose of propofol required to produce loss of consciousness. METHODS Forty female unpremedicated patients were assigned in a random blind design to receive either 2 mg physostigmine or equal volume of normal saline i.v. five minutes before induction of anaesthesia with propofol. All patients received general anaesthesia for breast surgery. Propofol was… CONTINUE READING