Physostigmine improves water maze performance following nucleus basalis magnocellularis lesions in rats

@article{Mandel1988PhysostigmineIW,
  title={Physostigmine improves water maze performance following nucleus basalis magnocellularis lesions in rats},
  author={Ron J. Mandel and Leon J. Thal},
  journal={Psychopharmacology},
  year={1988},
  volume={96},
  pages={421-425}
}
Bilateral excitotoxic lesions of the nucleus basalis magnocellularis in rats were used along with testing in the water maze task to assess whether inhibition of acetylcholinesterase with physostigmine would reverse the lesion-induced impairment. Rats were lesioned bilaterally in stages using ibotenic acid and then behaviorally tested 3 weeks after surgery. Lesioned animals were administered one of three doses of physostigmine (0.06, 0.19, or 0.32 mg/kg) or vehicle solution 15 min prior to water… CONTINUE READING
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The effect of training schedule in the Morris water maze on rats with nucleus basalis lesions

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AFI02B: a novel putative M1 agonist reverses AF64A-induced cognitive impairments in rats

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