Physostigmine as a Treatment for Gamma-Hydroxybutyrate Toxicity: A Review

@article{Traub2002PhysostigmineAA,
  title={Physostigmine as a Treatment for Gamma-Hydroxybutyrate Toxicity: A Review},
  author={Stephen J. Traub and Lewis S. Nelson and Robert S. Hoffman},
  journal={Journal of Toxicology: Clinical Toxicology},
  year={2002},
  volume={40},
  pages={781 - 787}
}
Introduction: Gamma-hydroxybutyrate is a potent sedative–hypnotic agent and a popular drug of abuse. In the United States, gamma-hydroxybutyrate is a Schedule I controlled substance (sodium oxybate) with orphan drug status for the treatment of narcolepsy within approved clinical studies. Physostigmine is a carbamate inhibitor of acetylcholinesterase that is reported to attenuate the sedative effects of a number of drugs, including gamma-hydroxybutyrate. We reviewed the literature that pertains… 
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