Physostigmine's impact on brief shock-induced hypoalgesia parallels its effect on memory.

@article{Meagher1998PhysostigminesIO,
  title={Physostigmine's impact on brief shock-induced hypoalgesia parallels its effect on memory.},
  author={Mary W. Meagher and Paul Illich and Juan A Salinas},
  journal={Neurobiology of learning and memory},
  year={1998},
  volume={70 3},
  pages={374-87}
}
Past research indicates that the anticholinergic drug scopolamine disrupts memory and environmentally induced hypoalgesia in rats. The present study examined the impact of the centrally active cholinesterase inhibitor physostigmine, which enhances memory and central cholinergic activity, on brief shock-induced hypoalgesia on the tail-flick test using Sprague-Dawley rats. It is reported that physostigmine (0.1 mg/kg) potentiates the magnitude of this hypoalgesia. Contrary to past research, our… CONTINUE READING
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