Physiopathology and treatment of fatigue in multiple sclerosis

  title={Physiopathology and treatment of fatigue in multiple sclerosis},
  author={Giancarlo Comi and Leitizia Leocani and Paolo Dionigi Rossi and Bruno Colombo},
  journal={Journal of Neurology},
Fatigue is a common symptom of patients with multiple sclerosis (MS). It is reported by about one-third of patients, and for many fatigue is the most disabling symptom. Fatigue may be associated with motor disturbances and/or mood disorders, which makes it very difficult to determine whether the fatigue is an aspect of these features or a result per se of the disease. Although peripheral mechanisms have some role in the pathogenesis of fatigue, in MS there are clear indications that the more… CONTINUE READING