Physiopathology and treatment of fatigue in multiple sclerosis

  title={Physiopathology and treatment of fatigue in multiple sclerosis},
  author={G. Comi and L. Leocani and P. Rossi and B. Colombo},
  journal={Journal of Neurology},
  • G. Comi, L. Leocani, +1 author B. Colombo
  • Published 2001
  • Medicine
  • Journal of Neurology
  • Abstracts Fatigue is a common symptom of patients with multiple sclerosis (MS). It is reported by about one-third of patients, and for many fatigue is the most disabling symptom. Fatigue may be associated with motor disturbances and/or mood disorders, which makes it very difficult to determine whether the fatigue is an aspect of these features or a result per se of the disease. Although peripheral mechanisms have some role in the pathogenesis of fatigue, in MS there are clear indications that… CONTINUE READING
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