Physiome-on-a-Chip: The Challenge of “Scaling” in Design, Operation, and Translation of Microphysiological Systems

@inproceedings{Stokes2015PhysiomeonaChipTC,
  title={Physiome-on-a-Chip: The Challenge of “Scaling” in Design, Operation, and Translation of Microphysiological Systems},
  author={CL Stokes and Murat Cirit and D. A. Lauffenburger},
  booktitle={CPT: pharmacometrics & systems pharmacology},
  year={2015}
}
Scaling of a microphysiological system (MPS) or physiome-on-a-chip is arguably two interrelated, modeling-based activities: on-platform scaling and in vitro-in vivo translation. This dual approach reduces the need to perfectly rescale and mimic in vivo physiology, an aspiration that is both extremely challenging and not substantively meaningful because of uncertain relevance of any specific physiological condition. Accordingly, this perspective offers a tractable approach for designing… CONTINUE READING

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