Physiology of incretins (GIP and GLP-1) and abnormalities in type 2 diabetes.

  title={Physiology of incretins (GIP and GLP-1) and abnormalities in type 2 diabetes.},
  author={Jean François Gautier and S-P Choukem and Julien Girard},
  journal={Diabetes & metabolism},
  volume={34 Suppl 2},
Incretin hormones are defined as intestinal hormones released in response to nutrient ingestion, which potentiate the glucose-induced insulin response. In humans, the incretin effect is mainly caused by two peptide hormones, glucose-dependent insulin releasing polypeptide (GIP), and glucagon-like peptide-1 (GLP-1). GIP is secreted by K cells from the upper small intestine while GLP-1 is mainly produced in the enteroendocrine L cells located in the distal intestine. Their effect is mediated… CONTINUE READING


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