Physiology of folate and vitamin B12 in health and disease.

  title={Physiology of folate and vitamin B12 in health and disease.},
  author={Patrick J Stover},
  journal={Nutrition reviews},
  volume={62 6 Pt 2},
  pages={S3-12; discussion S13}
Folate is a water-soluble B-vitamin and enzymatic cofactor that is necessary for the synthesis of purine and thymidine nucleotides and for the synthesis of methionine from homocysteine. Impairment of folate-mediated one-carbon metabolic pathways can result from B-vitamin deficiencies and/or single nucleotide polymorphisms, and increases risk for pathologies, including cancer and cardiovascular disease, and developmental anomalies including neural tube defects. Although several well validated… CONTINUE READING


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