Physiology of folate and vitamin B12 in health and disease.

@article{Stover2004PhysiologyOF,
  title={Physiology of folate and vitamin B12 in health and disease.},
  author={Patrick J Stover},
  journal={Nutrition reviews},
  year={2004},
  volume={62 6 Pt 2},
  pages={S3-12; discussion S13}
}
Folate is a water-soluble B-vitamin and enzymatic cofactor that is necessary for the synthesis of purine and thymidine nucleotides and for the synthesis of methionine from homocysteine. Impairment of folate-mediated one-carbon metabolic pathways can result from B-vitamin deficiencies and/or single nucleotide polymorphisms, and increases risk for pathologies, including cancer and cardiovascular disease, and developmental anomalies including neural tube defects. Although several well validated… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 151 extracted citations

Role of folate in nonalcoholic fatty liver disease.

Canadian journal of physiology and pharmacology • 2017
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…