Physiology of blood-brain interfaces in relation to brain disposition of small compounds and macromolecules.

@article{Strazielle2013PhysiologyOB,
  title={Physiology of blood-brain interfaces in relation to brain disposition of small compounds and macromolecules.},
  author={Nathalie Strazielle and Jean-François Ghersi-Egea},
  journal={Molecular pharmaceutics},
  year={2013},
  volume={10 5},
  pages={1473-91}
}
The brain develops and functions within a strictly controlled environment resulting from the coordinated action of different cellular interfaces located between the blood and the extracellular fluids of the brain, which include the interstitial fluid and the cerebrospinal fluid (CSF). As a correlate, the delivery of pharmacologically active molecules and especially macromolecules to the brain is challenged by the barrier properties of these interfaces. Blood-brain interfaces comprise both the… CONTINUE READING
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