Physiology of IgA and IgA Deficiency

@article{CunninghamRundles2004PhysiologyOI,
  title={Physiology of IgA and IgA Deficiency},
  author={Charlotte Cunningham-Rundles},
  journal={Journal of Clinical Immunology},
  year={2004},
  volume={21},
  pages={303-309}
}
Although secretory immunoglobulin A (IgA) is important in mucosal immunity, selective IgA deficiency is the most common primary immunodeficiency of humans. In most cases this defect is not associated with any illness. The reasons for this are unknown, but other immunological compensations might provide sufficient or complete restitution. Alternatively, it is possible that IgA deficiency alone may not predispose to disease, but additional immunological abnormalities might be present in… 
Selective IgA Deficiency
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  • Medicine, Biology
    Journal of Clinical Immunology
  • 2009
TLDR
Better understanding of the production and function of IgA is essential in elucidating the disease mechanism in IgA deficiency, and Alterations in transmembrane activator and calcium modulator and cyclophilin ligand interactor gene appear to act as disease-modifying mutations in both IgC deficiency and common variable immunodeficiency.
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TLDR
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TLDR
This review focuses on some important genes, including TNFRSF13B (encoding TACI), associated with SIgAD and the involvement of epigenetics, and environmental factors, including the gut microbiota, in the development ofSIgAD.
The Epidemiology and Clinical Presentations of Atopic Diseases in Selective IgA Deficiency
TLDR
The aim of the study is to summarize the connection between selective IgA deficiency and atopic diseases and hypothesized that allergic diseases are more common in patients diagnosed with this particular PID.
Autoimmunity in IgA Deficiency: Revisiting the Role of IgA as a Silent Housekeeper
TLDR
A hypothesis is proposed to explain the high association with autoimmune phenomena of IgA deficiency, which leads to deactivation of several activating pathways of the immune system including immunoreceptors that bear ITAM motif and ITAM-independent receptors, and inflammatory reactions and auto-immune process would be prevented.
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References

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TLDR
Healthy individuals with selective IgA deficiency did not have increased concentrations of salivary IgM compared to infectious-prone patients and there was no correlation found between proneness to infections and HLA antigens or between salivARY IgM or IgG levels and Hla antigen levels in this patient material.
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TLDR
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TLDR
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TLDR
Mice with targeted deletion of the IgA switch and constant regions are completely deficient in IgA and exhibit altered expression of other Ig isotypes, notably IgM, IgG2b, Igg3, and IgE, but otherwise have normal lymphocyte development, proliferative responses, and cytokine production.
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TLDR
The term `selective IgAD' should be reserved for those individuals who do not have identi®able disorders which are known to be associated with low IgA levels (see below), but in many cases a simultaneous change in the IgG subclass pattern is seen with a lack of speci®c anti-polysaccharide antibodies of the Igg2 subclass.
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TLDR
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TLDR
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