Physiology of IgA and IgA Deficiency

  title={Physiology of IgA and IgA Deficiency},
  author={C. Cunningham-Rundles},
  journal={Journal of Clinical Immunology},
  • C. Cunningham-Rundles
  • Published 2004
  • Biology, Medicine
  • Journal of Clinical Immunology
  • Although secretory immunoglobulin A (IgA) is important in mucosal immunity, selective IgA deficiency is the most common primary immunodeficiency of humans. In most cases this defect is not associated with any illness. The reasons for this are unknown, but other immunological compensations might provide sufficient or complete restitution. Alternatively, it is possible that IgA deficiency alone may not predispose to disease, but additional immunological abnormalities might be present in… CONTINUE READING
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