Physiology and role of irisin in glucose homeostasis

  title={Physiology and role of irisin in glucose homeostasis},
  author={Nikolaos Perakakis and Georgios A. Triantafyllou and Jos{\'e} Fern{\'a}ndez-Real and Joo Young Huh and Kyung Hee Park and Jochen Seufert and Christos Socrates Mantzoros},
  journal={Nature Reviews Endocrinology},
Irisin is a myokine that leads to increased energy expenditure by stimulating the 'browning' of white adipose tissue. In the first description of this hormone, increased levels of circulating irisin, which is cleaved from its precursor fibronectin type III domain-containing protein 5, were associated with improved glucose homeostasis by reducing insulin resistance. Consequently, several studies attempted to characterize the role of irisin in glucose regulation, but contradictory results have… CONTINUE READING
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