Physiology and pharmacology of the enteroendocrine hormone glucagon-like peptide-2.

  title={Physiology and pharmacology of the enteroendocrine hormone glucagon-like peptide-2.},
  author={Daniel J Drucker and Bernardo Yusta},
  journal={Annual review of physiology},
Glucagon-like peptide-2 (GLP-2) is a 33-amino-acid proglucagon-derived peptide secreted from enteroendocrine L cells. GLP-2 circulates at low basal levels in the fasting period, and plasma levels rise rapidly after food ingestion. Renal clearance and enzymatic inactivation control the elimination of bioactive GLP-2. GLP-2 increases mesenteric blood flow and activates proabsorptive pathways in the gut, facilitating nutrient absorption. GLP-2 also enhances gut barrier function and induces… CONTINUE READING


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Glucagon-like peptide 2 induces vasoactive intestinal polypeptide expression in enteric neurons via phophatidylinositol-3 kinase-γ signalling

  • E de Heuvel, LE Wallace, KA Sharkey, DL. Sigalet
  • Am. J. Physiol. Endocrinol. Metab
  • 2012
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