Physiology and pathophysiology of the vasopressin-regulated renal water reabsorption

@article{Boone2008PhysiologyAP,
  title={Physiology and pathophysiology of the vasopressin-regulated renal water reabsorption},
  author={Michelle Boone and Peter M T Deen},
  journal={Pflugers Archiv },
  year={2008},
  volume={456},
  pages={1005 - 1024}
}
To prevent dehydration, terrestrial animals and humans have developed a sensitive and versatile system to maintain their water homeostasis. In states of hypernatremia or hypovolemia, the antidiuretic hormone vasopressin (AVP) is released from the pituitary and binds its type-2 receptor in renal principal cells. This triggers an intracellular cAMP signaling cascade, which phosphorylates aquaporin-2 (AQP2) and targets the channel to the apical plasma membrane. Driven by an osmotic gradient, pro… CONTINUE READING

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