Physiology and pathophysiology of the interstitial cell of Cajal: from bench to bedside. II. Gastric motility: lessons from mutant mice on slow waves and innervation.

@article{Huizinga2001PhysiologyAP,
  title={Physiology and pathophysiology of the interstitial cell of Cajal: from bench to bedside. II. Gastric motility: lessons from mutant mice on slow waves and innervation.},
  author={Jan D. Huizinga},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2001},
  volume={281 5},
  pages={G1129-34}
}
  • Jan D. Huizinga
  • Published 2001 in
    American journal of physiology. Gastrointestinal…
The stomach harbors a network of interstitial cells of Cajal (ICC) associated with Auerbach's plexus as well as intramuscular ICC within the muscle layers that make close apposition contact with nerve varicosities. ICC are critical for slow-wave generation, making ICC the pacemaker cells of the gut, allowing rhythmic peristaltic motor patterns in the mid- and distal stomach. ICC also play a role in neurotransmission, but its importance relative to direct muscle innervation is still under… CONTINUE READING