Physiology and pathophysiology of the 5-HT3 receptor.

  title={Physiology and pathophysiology of the 5-HT3 receptor.},
  author={Lothar Faerber and Ulrike Haus and Michael Spaeth and Sabine Drechsler},
  journal={Scandinavian journal of rheumatology. Supplement},
The 5-HT3 receptor is a ligand-gated cation channel located in the central and peripheral nervous system; it has also been detected on a variety of other cells. In the periphery, it is found on autonomic neurons and on neurons of the sensory and enteric nervous system. In the CNS, the 5-HT3 receptor has been localized in the area postrema, nucleus tractus solitarii, nucleus vaudatus, nucleus accumbens, amygdala, hippocampus, entorhinal, frontal, cingulate cortex, and in the dorsal horn ganglia… CONTINUE READING