Physiology and pathophysiology of renal aquaporins.

  title={Physiology and pathophysiology of renal aquaporins.},
  author={Tae-Hwan Kwon and Henrik Hager and Lene N. Nejsum and Mogens Larsen Andersen and J{\o}rgen Fr{\o}kiaer and S{\o}ren Steen Nielsen},
  journal={Seminars in nephrology},
  volume={21 3},
The discovery of aquaporin-1 (AQP1) by Agre and associates answered the longstanding biophysical question of how water specifically crosses biological membranes. In the kidney at least 7 aquaporins are expressed at distinct sites. AQP1 is extremely abundant in the proximal tubule and descending thin limb and is essential for urinary concentration. AQP2 is exclusively expressed in the principal cells of the connecting tubule and collecting duct and is the predominant vasopressin-regulated water… 

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