Physiology and pathophysiology of proteinase-activated receptors (PARs): role of tryptase/PAR-2 in vascular endothelial barrier function.

@article{Itoh2005PhysiologyAP,
  title={Physiology and pathophysiology of proteinase-activated receptors (PARs): role of tryptase/PAR-2 in vascular endothelial barrier function.},
  author={Yoshinori I Itoh and Toshiaki Sendo and Ryozo Oishi},
  journal={Journal of pharmacological sciences},
  year={2005},
  volume={97 1},
  pages={14-9}
}
Proteinase-activated receptor-2 (PAR-2) plays important roles in a variety of pathophysiological functions, including inflammatory responses and nociception. In this minireview, we describe the role of PAR-2 in acute inflammatory responses in lungs associated with iodinated radiographic contrast medium (RCM). Intravenous injection of RCM to rats induces lung injury characterized by vascular hyperpermeability, edema, and respiratory depression. Nafamostat, which is found to be the most potent… CONTINUE READING