Physiology and pathophysiology of androgen action.

  title={Physiology and pathophysiology of androgen action.},
  author={Olaf Hiort and P. M. Holterhus and Esther M Nitsche},
  journal={Bailliere's clinical endocrinology and metabolism},
  volume={12 1},
Knowledge of the physiology of male sexual differentiation and the clinical presentation of androgen insensitivity syndromes (AIS) has led to an increasing understanding of the mechanisms of androgen action. Androgens induce their specific response via the androgen receptor (AR), which in turn regulates the transcription of androgen-responsive target genes. The androgen-dependent development of male genital structures and the induction of the normal male phenotype depends on the presence of an… CONTINUE READING


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