Physiology and gene expression characteristics of carcinogen-initiated and tumor-transformed glial progenitor cells derived from the CNS of methylnitrosourea (MNU)-treated Sprague-Dawley rats.

@article{Kokkinakis2004PhysiologyAG,
  title={Physiology and gene expression characteristics of carcinogen-initiated and tumor-transformed glial progenitor cells derived from the CNS of methylnitrosourea (MNU)-treated Sprague-Dawley rats.},
  author={Demetrius M. Kokkinakis and Elisabeth Jane Rushing and Mohammed Momin Shareef and M. M. Mohamed Ahmed and Shuting Yang and Ujjal K Singha and Jianhua Luo},
  journal={Journal of neuropathology and experimental neurology},
  year={2004},
  volume={63 11},
  pages={1182-99}
}
Glial progenitors from the brain of normal adult Sprague-Dawley rats were compared to their initiated and malignant counterparts that were isolated from apparently normal brains of animals exposed to methylnitrosourea (MNU). Fibroblast growth factor-2 (FGF-2) or platelet-derived growth factor (PDGF)-A or -B induced differentiation of normal progenitors to a pro-astrocytic or oligodendrocytic morphology, respectively, whereas the combination of these factors resulted in their terminal… CONTINUE READING