Physiology and function of the erythropoietin receptor.

  title={Physiology and function of the erythropoietin receptor.},
  author={Akihiko Yoshimura and Hiroyuki Misawa},
  journal={Current opinion in hematology},
  volume={5 3},
Interaction between erythropoietin (EPO) and its membrane receptor induces the proliferation and differentiation of erythroid progenitors. Targeted disruption of the EPO receptor (EPOR) gene have clearly demonstrated the importance of the EPO/EPOR system for definitive erythroid cell survival and proliferation; however, in vitro rescue experiments have revealed that it is not essential for differentiation. The three-dimensional structure of the EPOR has been determined, and a biologically… CONTINUE READING

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