Physiologically based pharmacokinetics model of primidone and its metabolites phenobarbital and phenylethylmalonamide in humans, rats, and mice.

@article{ElMasri1998PhysiologicallyBP,
  title={Physiologically based pharmacokinetics model of primidone and its metabolites phenobarbital and phenylethylmalonamide in humans, rats, and mice.},
  author={Hisham A. El-Masri and Christopher J. Portier},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1998},
  volume={26 6},
  pages={585-94}
}
Physiologically based pharmacokinetic modeling of the parent chemical primidone and its two metabolites phenobarbital and phenylethylmalonamide (PEMA) was applied to investigate the differences of primidone metabolism among humans, rats, and mice. The model simulated previously published pharmacokinetic data of the parent chemical and its metabolites in plasma and brain tissues from separate studies of the three species. Metabolism of primidone and its metabolites varied widely among a sample… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 15 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 29 references

Effect of silica and volcanic ash on the content of lung alveolar and tissue phospholipids

  • DJ Kornburst, GE Hatch
  • Environ Res
  • 1984
Highly Influential
2 Excerpts

Similar Papers

Loading similar papers…