Physiologically based pharmacokinetics and the risk assessment process for methylene chloride.

@article{Andersen1987PhysiologicallyBP,
  title={Physiologically based pharmacokinetics and the risk assessment process for methylene chloride.},
  author={Melvin E. Andersen and Harvey J. Clewell and Michael L. Gargas and F. Andrew Smith and Richard H Reitz},
  journal={Toxicology and applied pharmacology},
  year={1987},
  volume={87 2},
  pages={185-205}
}
Methylene chloride (dichloromethane, DCM) is metabolized by two pathways: one dependent on oxidation by mixed function oxidases (MFO) and the other dependent on glutathione S-transferases (GST). A physiologically based pharmacokinetic (PB-PK) model based on knowledge of these pathways was used to describe the metabolism of DCM in four mammalian species (mouse, rat, hamster, and humans). Kinetic constants for the model were derived from in vivo experiments or the literature. The model was… CONTINUE READING

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