Physiologically based pharmacokinetic models for the transport of trichloroethylene in adipose tissue.

@article{Albanese2002PhysiologicallyBP,
  title={Physiologically based pharmacokinetic models for the transport of trichloroethylene in adipose tissue.},
  author={Richard A. Albanese and H. T. Banks and Marina V. Evans and Laura K. Potter},
  journal={Bulletin of mathematical biology},
  year={2002},
  volume={64 1},
  pages={97-131}
}
In this paper we present three physiologically based pharmacokinetic (PBPK) models for the systemic transport of trichloroethylene (TCE), with a focus on the adipose, or fat tissue. TCE is a widespread environmental contaminant, and has been shown to produce toxic effects in both animals and humans. A key characteristic of TCE is its tendency to accumulate in fat tissue, which has a major impact on the overall systemic disposition of TCE. Here we use PBPK models to predict the dynamics of TCE… CONTINUE READING

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