Physiologically-based pharmacokinetic modeling of target-mediated drug disposition of bortezomib in mice

Abstract

Bortezomib is a reversible proteasome inhibitor with potent antineoplastic activity that exhibits dose- and time-dependent pharmacokinetics (PK). Proteasome-mediated bortezomib disposition is proposed as the primary source of its nonlinear and apparent nonstationary PK behavior. Single intravenous (IV) doses of bortezomib (0.25 and 1 mg/kg) were… (More)
DOI: 10.1007/s10928-015-9445-x

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