Physiologically based pharmacokinetic modeling of styrene and styrene oxide respiratory-tract dosimetry in rodents and humans.

@article{Sarangapani2002PhysiologicallyBP,
  title={Physiologically based pharmacokinetic modeling of styrene and styrene oxide respiratory-tract dosimetry in rodents and humans.},
  author={Ramesh Sarangapani and Justin G. Teeguarden and George Cruzan and Harvey J. Clewell and Melvin E. Andersen},
  journal={Inhalation toxicology},
  year={2002},
  volume={14 8},
  pages={789-834}
}
Styrene (ST) is widely used to manufacture resins, glass-reinforced plastics, and a number of commercially important polymers (Miller et al., 1994). Chronic ST inhalation studies in rodents have demonstrated unique species specificity in the resulting pulmonary toxicity and carcinogenicity. Increased incidences of pulmonary bronchioloalveolar tumors have been observed in mice, but not in rats. No other tumor type was increased significantly in either species. Clara cells lining the respiratory… CONTINUE READING