Physiologically based pharmacokinetic modeling of PLGA nanoparticles with varied mPEG content

@inproceedings{Li2012PhysiologicallyBP,
  title={Physiologically based pharmacokinetic modeling of PLGA nanoparticles with varied mPEG content},
  author={Mingguang Li and Zoi Panagi and Konstantinos Avgoustakis and Joshua James Reineke},
  booktitle={International journal of nanomedicine},
  year={2012}
}
Biodistribution of nanoparticles is dependent on their physicochemical properties (such as size, surface charge, and surface hydrophilicity). Clear and systematic understanding of nanoparticle properties' effects on their in vivo performance is of fundamental significance in nanoparticle design, development and optimization for medical applications, and toxicity evaluation. In the present study, a physiologically based pharmacokinetic model was utilized to interpret the effects of nanoparticle… CONTINUE READING
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