Physiologically based pharmacokinetic modeling in drug discovery and development: a pharmaceutical industry perspective.

@article{Jones2015PhysiologicallyBP,
  title={Physiologically based pharmacokinetic modeling in drug discovery and development: a pharmaceutical industry perspective.},
  author={Hal Jones and Y Chen and Christopher R. Gibson and Tycho Heimbach and Neil Parrott and Sheila Annie Peters and Jan Snoeys and Vijay V. Upreti and Mingli Zheng and Stephen D. Hall},
  journal={Clinical pharmacology and therapeutics},
  year={2015},
  volume={97 3},
  pages={247-62}
}
The application of physiologically based pharmacokinetic (PBPK) modeling has developed rapidly within the pharmaceutical industry and is becoming an integral part of drug discovery and development. In this study, we provide a cross pharmaceutical industry position on "how PBPK modeling can be applied in industry" focusing on the strategies for application of PBPK at different stages, an associated perspective on the confidence and challenges, as well as guidance on interacting with regulatory… CONTINUE READING

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