Physiologically based pharmacokinetic model for methanol in rats, monkeys, and humans.

@article{Horton1992PhysiologicallyBP,
  title={Physiologically based pharmacokinetic model for methanol in rats, monkeys, and humans.},
  author={V L Horton and Mark A Higuchi and Donald E. Rickert},
  journal={Toxicology and applied pharmacology},
  year={1992},
  volume={117 1},
  pages={26-36}
}
The pharmacokinetics of methanol and formate were characterized in male Fischer-344 rats and rhesus monkeys exposed to methanol vapor concentrations between 50 and 2000 ppm for 6 hr. End-of-exposure blood methanol concentrations were not directly proportional to the atmospheric concentration. The methanol exposures did not cause an elevation in blood formate concentrations. After an intravenous dose of [14C]methanol in rats, metabolism, exhalation, and renal excretion contributed 96.6, 2.6, and… CONTINUE READING
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