Physiologically based pharmacokinetic model parameter estimation and sensitivity and variability analyses for acrylonitrile disposition in humans.

@article{Sweeney2003PhysiologicallyBP,
  title={Physiologically based pharmacokinetic model parameter estimation and sensitivity and variability analyses for acrylonitrile disposition in humans.},
  author={Lisa M. Sweeney and Michael L. Gargas and Dale E Strother and Gregory L Kedderis},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2003},
  volume={71 1},
  pages={27-40}
}
A physiologically based pharmacokinetic (PBPK) model of acrylonitrile (ACN) and cyanoethylene oxide (CEO) disposition in humans was developed and is based on human in vitro data and scaling from a rat model (G. L. Kedderis et al., 1996, TOXICOL: Appl. Pharmacol.140, 422-435) for application to risk assessment. All of the major biotransformation and reactivity pathways, including metabolism of ACN to glutathione conjugates and CEO, reaction rates of ACN and CEO with glutathione and tissues, and… CONTINUE READING