Physiologically-based pharmacokinetic analysis of grepafloxacin.

  title={Physiologically-based pharmacokinetic analysis of grepafloxacin.},
  author={Yutsuki Nakajima and Kaoru Hattori and Machiko Shinsei and Nobuyoshi Matsunaga and Hisashi Iizasa and Hiroyuki Sasabe and Hidero Akiyama and G Miyanmoto and Emi Nakashima},
  journal={Biological & pharmaceutical bulletin},
  volume={23 9},
Grepafloxacin (GPFX) is a synthetic new quinolone antimicrobial agent that possesses an extensive tissue distribution and exhibits a strong antibacterial activity in vivo. In this study, the tissue distribution characteristics of GPFX were examined using tissue concentration-time profiles following intravenous administration to rats. Subsequently, the pharmacokinetics of GPFX were analyzed based on the physiological pharmacokinetic model. The tissue-to-plasma partition coefficients (Kp) of GPFX… CONTINUE READING