Physiologically based pharmacokinetic (PB-PK) models in the study of the disposition and biological effects of xenobiotics and drugs.

@article{Andersen1995PhysiologicallyBP,
  title={Physiologically based pharmacokinetic (PB-PK) models in the study of the disposition and biological effects of xenobiotics and drugs.},
  author={Melvin E. Andersen},
  journal={Toxicology letters},
  year={1995},
  volume={82-83},
  pages={341-8}
}
Physiologically based pharmacokinetic (PB-PK) models have been used to study the mechanisms of disposition of drugs and xenobiotics for almost 70 years. Their widespread application in toxicology began 15 years ago with models for polychlorinated biphenyls and other persistent lipophilic compounds. Quantitative applications of PB-PK moels in carcinogen risk assessment date to the development of a number of PB-PK models for dichloromethane in the mid 1980s. The expanding use of these models is… CONTINUE READING