Physiologically based pharmacokinetic (PBPK) modeling of disposition of epiroprim in humans.

  title={Physiologically based pharmacokinetic (PBPK) modeling of disposition of epiroprim in humans.},
  author={Olivier Luttringer and Frank-Peter Theil and Patrick Poulin and Anne H Schmitt-Hoffmann and Theodor Walter Guentert and Thierry Lav{\'e}},
  journal={Journal of pharmaceutical sciences},
  volume={92 10},
The objective of this study was to use in synergy physiologically based and empirical approaches to estimate the drug-specific input parameters of PBPK models of disposition to simulate the plasma concentration-time profile of epiroprim in human. The estimated input parameters were the tissue:plasma partition coefficients (Pt:p) for distribution and the blood clearance (CL) for the in vivo conditions. Epiroprim represents a challenge for such methods, because it shows large interspecies… CONTINUE READING

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