Physiologically based pharmacokinetic (PBPK) modeling of caffeine and theophylline in neonates and adults: implications for assessing children's risks from environmental agents.

@article{Ginsberg2004PhysiologicallyBP,
  title={Physiologically based pharmacokinetic (PBPK) modeling of caffeine and theophylline in neonates and adults: implications for assessing children's risks from environmental agents.},
  author={Gary L. Ginsberg and Dale B. Hattis and Abel Russ and Babasaheb Sonawane},
  journal={Journal of toxicology and environmental health. Part A},
  year={2004},
  volume={67 4},
  pages={297-329}
}
Children's risks can differ from those in adults for numerous reasons, one being differences in the pharmacokinetic handling of chemicals. Immature metabolism and a variety of other factors in neonates can affect chemical disposition and clearance. These factors can be incorporated into physiologically based pharmacokinetic (PBPK) models that simulate the fate of environmental toxicants in both children and adults. PBPK models are most informative when supported by empirical data, but typically… CONTINUE READING

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