Physiologically-based pharmacokinetic (PBPK) model to predict IgG tissue kinetics in wild-type and FcRn-knockout mice

@article{Garg2007PhysiologicallybasedP,
  title={Physiologically-based pharmacokinetic (PBPK) model to predict IgG tissue kinetics in wild-type and FcRn-knockout mice},
  author={Amit Garg and Joseph P Balthasar},
  journal={Journal of Pharmacokinetics and Pharmacodynamics},
  year={2007},
  volume={34},
  pages={687-709}
}
Although it is known that FcRn, the neonatal Fc-receptor, functions to protect immune gamma globulin (IgG) from elimination, the influence of FcRn on the tissue distribution of IgG has not been quantified. In the present work, a physiologically-based pharmacokinetic (PBPK) model has been developed to characterize and predict IgG disposition in plasma and in tissues. The model includes nine major compartments, connected in an anatomical manner, to represent tissues known to play a significant… CONTINUE READING
Highly Influential
This paper has highly influenced 16 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 110 extracted citations

A generic whole body physiologically based pharmacokinetic model for therapeutic proteins in PK-Sim

Journal of Pharmacokinetics and Pharmacodynamics • 2017
View 10 Excerpts
Highly Influenced

MPBPK-TMDD models for mAbs: alternative models, comparison, and identifiability issues

Journal of Pharmacokinetics and Pharmacodynamics • 2018
View 3 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 63 references

Antibody pharmacokinetics and pharmacodynamics.

Journal of pharmaceutical sciences • 2004
View 3 Excerpts

Monoclonal antibodies market

Nature Reviews Drug Discovery • 2004

Pavolu A (2004) Monoclonal antibodies

J Reichert
market. Nat Rev Drug Discov • 2004
View 1 Excerpt

Fundamental immunology

WE Paul
2003
View 1 Excerpt

Similar Papers

Loading similar papers…