Physiologically based pharmacokinetic/pharmacodynamic modeling of the toxicologic interaction between carbon tetrachloride and Kepone

@article{ElMasri1996PhysiologicallyBP,
  title={Physiologically based pharmacokinetic/pharmacodynamic modeling of the toxicologic interaction between carbon tetrachloride and Kepone},
  author={Hisham A. El-Masri and Russell S. Thomas and G. Rob Sabados and Jenny K. Phillips and Alexander A. Constan and Stephen A. Benjamin and Melvin E. Andersen and Harihara M. Mehendale and Raymond S. H. Yang},
  journal={Archives of Toxicology},
  year={1996},
  volume={70},
  pages={704-713}
}
 Carbon tetrachloride (CCl4) lethality in Sprague-Dawley rats is greatly amplified by pretreatment of Kepone (decachlorooctahydro-1,3,2-metheno-2H-cyclobuta[cd]pentalen-2-one). The increase in lethality was attributed to the obstruction of liver regenerative processes. These processes are essential for restoring the liver to its full functional capacity following injury by CCl4. Based on the available mechanistic information on Kepone/CCl4 interaction, a physiologically based pharmacokinetic… CONTINUE READING
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