Physiologically based liver modeling and risk assessment.

  title={Physiologically based liver modeling and risk assessment.},
  author={Peter J. Robinson},
  journal={Risk analysis : an official publication of the Society for Risk Analysis},
  volume={12 1},
Because of the inherent complexity of biological systems, there is often a choice between a number of apparently equally applicable physiologically based models to describe uptake and metabolism processes in toxicology or risk assessment. These models may fit the particular data sets of interest equally well, but may give quite different parameter estimates or predictions under different (extrapolated) conditions. Such competing models can be discriminated by a number of methods, including… CONTINUE READING