Physiologically Based Pharmacokinetic Modeling to Investigate Regional Brain Distribution Kinetics in Rats

@article{Westerhout2012PhysiologicallyBP,
  title={Physiologically Based Pharmacokinetic Modeling to Investigate Regional Brain Distribution Kinetics in Rats},
  author={Joost Westerhout and Bart Ploeger and J G E Smeets and Meindert Danhof and Elizabeth C. de Lange},
  journal={The AAPS Journal},
  year={2012},
  volume={14},
  pages={543-553}
}
One of the major challenges in the development of central nervous system (CNS)-targeted drugs is predicting CNS exposure in human from preclinical data. In this study, we present a methodology to investigate brain disposition in rats using a physiologically based modeling approach aiming at improving the prediction of human brain exposure. We specifically focused on quantifying regional diffusion and fluid flow processes within the brain. Acetaminophen was used as a test compound as it is not… CONTINUE READING
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