Physiological stimulation regulates the exocytic mode through calcium activation of protein kinase C in mouse chromaffin cells.

@article{Fulop2006PhysiologicalSR,
  title={Physiological stimulation regulates the exocytic mode through calcium activation of protein kinase C in mouse chromaffin cells.},
  author={Tiberiu G. Fulop and Corey Shepard. Smith},
  journal={The Biochemical journal},
  year={2006},
  volume={399 1},
  pages={
          111-9
        }
}
Adrenal medullary chromaffin cells release catecholamines and neuropeptides in an activity-dependent manner controlled by the sympathetic nervous system. Under basal sympathetic tone, catecholamines are preferentially secreted. During acute stress, increased sympathetic firing evokes release of both catecholamines as well as neuropeptides. Both signalling molecules are co-packaged in the same large dense core granules, thus release of neuropeptide transmitters must be regulated after granule… CONTINUE READING

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