Physiological significance of volume-regulatory transporters.

  title={Physiological significance of volume-regulatory transporters.},
  author={W Charles O'neill},
  journal={The American journal of physiology},
  volume={276 5 Pt 1},
Research over the past 25 years has identified specific ion transporters and channels that are activated by acute changes in cell volume and that serve to restore steady-state volume. The mechanism by which cells sense changes in cell volume and activate the appropriate transporters remains a mystery, but recent studies are providing important clues. A curious aspect of volume regulation in mammalian cells is that it is often absent or incomplete in anisosmotic media, whereas complete volume… CONTINUE READING
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