Physiological significance of two common haplotypes of human angiotensinogen using gene targeting in the mouse.

@article{Cvetkovic2002PhysiologicalSO,
  title={Physiological significance of two common haplotypes of human angiotensinogen using gene targeting in the mouse.},
  author={Branimir Cvetkovic and Henry L. Keen and Xiaoji Zhang and Deborah Davis and Baoli Yang and Curt D. Sigmund},
  journal={Physiological genomics},
  year={2002},
  volume={11 3},
  pages={253-62}
}
Angiotensinogen (AGT) was the first gene to be genetically linked to hypertension in humans. Analysis of the gene sequence identified a number of polymorphisms, several of which were reported associated with increased blood pressure (BP) or other cardiovascular diseases. One haplotype of the human AGT (hAGT) gene consisting of an allele at the -6 (A vs. G) position in the promoter and the sequence encoding amino acid 235 (Thr vs. Met) attracted the most attention and has been the subject of… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 15 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 46 references

Similar Papers

Loading similar papers…