Physiological roles of leupeptin and extracellular proteases in mycelium development of Streptomyces exfoliatus SMF13.

@article{Kim1995PhysiologicalRO,
  title={Physiological roles of leupeptin and extracellular proteases in mycelium development of Streptomyces exfoliatus SMF13.},
  author={Ik-sang Kim and Katherine J Lee},
  journal={Microbiology},
  year={1995},
  volume={141 ( Pt 4)},
  pages={1017-25}
}
Streptomyces exfoliatus SMF13 produced leupeptin, chymotrypsin-like protease (CTP), metalloprotease, and trypsin-like protease (TLP) extracellularly. The activity of TLP was specifically inhibited by leupeptin. Production of leupeptin was closely associated with growth but leupeptin was inactivated by leupeptin-inactivating protein (LIP) when growth reached the stationary phase in submerged cultures, or when aerial mycelia started to form on surface cultures. Autolysis of mycelia after the… CONTINUE READING

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